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Best over counter medications - October 2025

Last Updated - October 4, 2025

1
Best Choice

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Zyrtec

Zyrtec 24 Hour Allergy Relief Tablets, Indoor & Outdoor Allergy Medicine with 10 mg Cetirizine Hydrochloride Antihistamine, Value Bundle of one, 90 ct Bottle & Three, 1 ct Travel Packs

Zyrtec

$43.89

More Details
Main highlights
- Relief of Allergy Symptoms: Delivers effective symptom relief for runny nose, sneezing, itchy, watery eyes, and itching of the nose or throat; starts working at hour one and is suitable for adults and children ages 6 and up
- FSA eligible and trusted brand: Zyrtec allergy relief tablets are FSA eligible and from the doctor-recommended over-the-counter oral antihistamine brand; bundle pack offers convenience and value for managing allergies anytime, anywhere
- Bundle pack convenience: Includes 90-count bottle and three 1-count travel packs for 93 total tablets; perfect for home or on-the-go allergy relief with trusted Zyrtec quality and value in every dose
- Allergy pills for adults: Each cetirizine 10 mg tablet is an over-the-counter medication designed for long-lasting relief from hay fever, upper respiratory allergies, and seasonal or year-round allergy symptoms
- 24-hour allergy relief: Fast-acting cetirizine hydrochloride 10mg antihistamine tablets provide powerful, prescription-strength relief from indoor and outdoor allergies, including pollen, dust, pet dander, and more. Starts working at hour 1
$43.89
2

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Advil

Advil Liqui-Gels minis Pain Reliever and Fever Reducer, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief - 200 Liquid Filled Capsules

Advil

$23.47

More Details
Main highlights
- Take these Advil mini Liqui-Gels as directed - the perfect addition to your college dorm room essentials
- Pain reliever and fever reducer for adults designed for fast absorption, with the same strength as regular size Advil Liqui-Gels
- One bottle of 200 Advil Liqui-Gels minis Pain Reliever and Fever Reducer Liquid Filled Capsules, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief
- Liqui-Gel Minis are easy to swallow - the perfect addition to your college dorm room essentials
- Headache medicine, back pain medicine and joint or minor arthritis pain reliever that are faster and stronger on tough pain than Tylenol Rapid Release Gels
- HSA and FSA eligible product
- Fever medicine and headache pain relief, period pain relief, joint pain medicine and back pain medication for adults and children 12 years and older
$23.47
3
Best Value
16% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Motrin
16% Off

Motrin IB Ibuprofen 200mg Tablets, Ibuprofen Pain & Fever Reliever for Headache, Backache, Muscular Aches, Menstrual Pain & Minor Arthritis Pain, Over-The-Counter NSAID Medicine, 225 ct

Motrin

$16.97

$20.24
(16% Off)

More Details
Main highlights
- Motrin IB ibuprofen tablets temporarily reduce fever and offer pain relief due to the common cold, minor pain of arthritis, headache, backache, toothache and menstrual cramps
- Motrin IB ibuprofen tablets are indicated for ages 12 years or older and are safe and effective when used as directed for fever and pain relief
- Get long-lasting pain relief with Motrin IB ibuprofen tablets. Adults and children 12 years and older, take one pain relief caplet every four to six hours while symptoms persist. If pain or fever does not respond, two caplets may be used
- Each Motrin IB tablet contains 200 milligrams of fast-acting ibuprofen pain relief medicine to help stop pain at its source and provide powerful pain relief when it counts
- 225-count bottle of Motrin IB tablets with the NSAID ibuprofen pain reliever offer fast acting & effective pain relief from minor aches and pains
$16.97
$20.24 (16% Off)
4

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Excedrin

Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms - 200 Count

Excedrin

$19.73

More Details
Main highlights
- One bottle of 2 Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms
- Head pain relief medicine delivers a powerful triple action formula with two pain relievers and an amplifier
- Excedrin migraine pain relief caplets combine acetaminophen, aspirin and caffeine
- Excedrin Migraine works in 3 ways to relieve migraines: it blocks pain signals, elevates your pain threshold and uses caffeine to enhance the pain relief effect
- Delivers migraine relief, including acting as a migraine headache pain reliever and relieving sensitivity to light and sound, and nausea
$19.73
5

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basic Care

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 1000 Count (Packaging may vary)

Amazon Basic Care

$15.03

$15.99
(6% Off)

More Details
Main highlights
- USE: Acetaminophen may be used as a pain reliever and fever reducer for adults and children 12 years and over
- PAIN: Pain may begin with an injury or illness, but could also originate with anything from a bad mattress to arthritisACUTE PAIN: Acute pain acts as an alarm such as with a bee sting or stubbing your toe and can last for a few moments or for longer
- ACTIVE INGREDIENT: Amazon Basic Care Extra Strength Pain Relief's active ingredient is Acetaminophen, 500 mg, which compares to the active ingredient of Extra Strength Tylenol CapletsAmazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, temporarily relieves minor aches and pains due to: the common cold, headache, backache, minor pain of arthritis, toothache, muscular aches, and premenstrual and menstrual cramps also temporarily reduces fever
- "Product may be manufactured in India or U.S."
$15.03
$15.99 (6% Off)

Best over counter medications - October 2025

Zyrtec 24 Hour Allergy Relief Tablets, Indoor & Outdoor Allergy Medicine with 10 mg Cetirizine Hydrochloride Antihistamine, Value Bundle of one, 90 ct Bottle & Three, 1 ct Travel Packs

Advil Liqui-Gels minis Pain Reliever and Fever Reducer, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief - 200 Liquid Filled Capsules

Motrin IB Ibuprofen 200mg Tablets, Ibuprofen Pain & Fever Reliever for Headache, Backache, Muscular Aches, Menstrual Pain & Minor Arthritis Pain, Over-The-Counter NSAID Medicine, 225 ct

Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms - 200 Count

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 1000 Count (Packaging may vary)

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