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Best digestive supplements - October 2025

Last Updated - October 4, 2025

1
Best Choice

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Zenwise Health

Zenwise Health Digestive Enzymes for Gut Health & Bloating Relief - Multi Enzymes Digestion Supplement with Probiotics, Bromelain & Papaya for Digestive Health Support - Men & Women - 180 Count

Zenwise Health

$39.97

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Main highlights
- Proven Probiotics – Guaranteed to arrive alive and work within hours in the small intestine where 90% of nutrient absorption occurs
- Plant-Based Formula - Pure vegetarian enzymes combined with prebiotic fiber nourish your microbiome while supporting healthy digestion and immune function – take 1 capsule before your meal to experience digestive delight
- Gas & Bloating Relief - Targeted enzymes work with beneficial microflora to ease uncomfortable bloating, reduce gas, and soothe digestive discomfort naturally
- Fast-Acting Enzymes – Powerful enzyme blend starts working immediately to break down food up to 39% more completely, and ease indigestion for rapid, noticeable relief
- 3-in-1 Formula – Blend of lab proven enzymes, clinically proven probiotics and prebiotics works synergistically to break down proteins, fats, and carbs while resorting digestive flora balance for optimal nutrient absorption and digestion maintain digestive wellness and promote regularity
$39.97
2

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Designs for Health

Designs for Health Digestzymes - Digestive Enzymes + Betaine Hydrochloride for Gas & Bloating Relief - Pepsin, Ox Bile, Lactase Enzyme & Lipase Enzymes for Digestion (60 Capsules)

Designs for Health

$31.99

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Main highlights
- Why Add Bile Salts to Your Digestive Enzyme Blend? Ox bile provides bile acids, which are key to the digestion of fat and fat-soluble vitamins. Ox bile digestive enzymes formulas can offer further support for malabsorption and maldigestion, including fats.*
- Support Food Breakdown + Nutrient Absorption - This digestive enzyme supplement is a multi enzyme blend of a proprietary blend of digestive enzymes alongside hcl betaine with pepsin to support gut health and optimal digestion of proteins, fats, and carbohydrates.*
- Pancreatic Enzymes + Betaine HCl - Protease DPP IV aids in the breakdown of casomorphin (from casein protein) and gluteomorphin (from gluten). Lactase enzyme helps break down the dairy sugar lactose, while lipase support fats and fat-soluble vitamins. The betaine hydrochloride supplement supports protein digestion and nutrient absorption.*
- Occasional Gas or Bloating After Meals? Enzymes for digestion may be helpful for those experiencing occasional gas after eating, constipation, or a feeling of fullness after eating only a small quantity of food.* The use of Digestzyme before meals may offer occasional mild bloating relief. Take one digestion supplement capsule before meals to support digestive gut health.*
- Clinically-Trusted Care - DFH is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.**
$31.99
3
23% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Physician's CHOICE
23% Off

Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT

Physician's CHOICE

$17.99

$23.52
(23% Off)

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Main highlights
- Science Backed - Our Digestive Enzyme Probiotics are crafted based on scientific research. We have partnered with expert physicians to help review our products & research. We strive to educate & help you with informed decisions regarding your health.
- Safety Assured Standard of Quality: Our Digestive Enzymes are 3rd-party tested for purity and potency. Each bottle is manufactured w/ love & care in the USA with strict quality control - using imported & domestic ingredients. No Refrigeration Needed
- Probiotics that Survive the Gut: Formulated with 3 soil-based probiotic strains - specifically selected due to their ability to survive the harsh gut environment. Along with Organic Prebiotics that fuel the growth of healthy bacteria in the gut.
- Dual Action Relief: Our powerful digestive enzymes aid with breaking down food while the prebiotics & probiotics promote digestive function in the gut. They work synergistically to provide relief from mealtime discomfort. One Month Supply
- Beat the Bloat & Say Goodbye to Meal Time Discomfort: 16 beneficial enzymes that digest proteins, carbs, fruits, veggies, beans, dairy, & fats to cover all diets. With SBO Probiotics & Prebiotics to aid digestion further - Your New Meal Time Hack! Same great product you love, with a new look. Packaging May Vary!
$17.99
$23.52 (23% Off)
4
23% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Garden of Life
23% Off

Garden of Life Dr Formulated Digestive Enzymes with Papain, Bromelain, Lipase for Digestion & Nutrient Absorption – Organic Digest+ - Vegan, Gluten-Free, Non-GMO, Tropical Fruit Flavor, 90 Chewables

Garden of Life

$23.79

$30.99
(23% Off)

More Details
Main highlights
- MADE FROM WHOLE FOODS: Dr. Perlmutter formulated Digest plus to be a full spectrum plant-based enzyme formula to aid the digestion of proteins, fats, and carbs; We’ve also included prebiotic fiber from Organic Acacia to support the good bacteria in your gut
- EXPERTLY FORMULATED: Our digestive supplement is proudly Dr. Formulated by David Perlmutter, MD and Third-Party Certified Non-GMO, Gluten-Free and Vegan; Made in the USA with no dairy, soy, gluten, peanuts or tree nuts
- CONVENIENCE IN MIND: Transport to the tropics after every last bite; Enjoy the benefits of Organic Digest plus in a tropical flavored, shelf stable tablet thats size makes it easy to take on the go; Adults chew 1 tablet after each meal or snack
- BREAK IT DOWN: Organic Digest plus offers 29 Certified Organic fruits and vegetables plus a select blend of 13 powerful digestive enzymes including amylase, bromelain, and lactase to help with digestion after meals
- BACKED BY SCIENCE: Our Dr. Formulated Organic Digest plus is the first-ever Certified Organic and Non-GMO digestive enzyme formula that is made from real food and is delivered using Clean Tablet Technology to ensure optimal nutrient absorption
$23.79
$30.99 (23% Off)
5
Best Value
54% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

NOW Foods
54% Off

NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

NOW Foods

$20.00

$43.99
(54% Off)

More Details
Main highlights
- SUPPORTS HEALTHY DIGESTION*: NOW Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion.* Take one capsule with a meal
- Packaged in the USA by a family owned and operated company since 1968
- GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
- CERTIFICATIONS/CLASSIFICATIONS: Soy Free, Made without Gluten, Keto Friendly
- BREAKS DOWN FATS, CARBS, AND PROTEINS*/OPTIMIZES NUTRIENT AVAILABILITY*: Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein*
$20.00
$43.99 (54% Off)

Best digestive supplements - October 2025

Zenwise Health Digestive Enzymes for Gut Health & Bloating Relief - Multi Enzymes Digestion Supplement with Probiotics, Bromelain & Papaya for Digestive Health Support - Men & Women - 180 Count

Designs for Health Digestzymes - Digestive Enzymes + Betaine Hydrochloride for Gas & Bloating Relief - Pepsin, Ox Bile, Lactase Enzyme & Lipase Enzymes for Digestion (60 Capsules)

Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT

Garden of Life Dr Formulated Digestive Enzymes with Papain, Bromelain, Lipase for Digestion & Nutrient Absorption – Organic Digest+ - Vegan, Gluten-Free, Non-GMO, Tropical Fruit Flavor, 90 Chewables

NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

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Metamucil, Fiber Capsules, 3-in-1 Psyllium Husk Fiber, 300 Capsules, Daily Fiber Supplement, Help support digestive health, heart health by lowering cholesterol†, and healthy blood sugar levels.